Kidney cancer is characterized by aberrant methylation of tissue specific enhancers that are prognostic for overall survival

PURPOSE: Even though recent studies have shown that genetic changes at enhancers can influence carcinogenesis, most methylomic studies have focused on changes at promoters. We used renal cell carcinoma (RCC), an incurable malignancy associated with mutations in epigenetic regulators, as a model to s...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Hu, Caroline Y., Mohtat, Davoud, Yu, Yiting, Ko, Yi-An, Shenoy, Niraj, Bhattacharya, Sanchari, Izquierdo, Maria C., Park, Ae Seo Deok, Giricz, Orsolya, Vellamkutla, Nishanth, Gundabolu, Krishna, Ware, Kristin, Bhagat, Tushar, Suzuki, Masako, Pullman, James, Liu, Shirley, Greally, John, Susztak, Katalin, Verma, Amit
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424050/
https://ncbi.nlm.nih.gov/pubmed/24916699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0494
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