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CDK9 inhibitors define elongation checkpoints at both ends of RNA polymerase II-transcribed genes
Transcription through early-elongation checkpoints requires phosphorylation of negative transcription elongation factors (NTEFs) by the cyclin-dependent kinase (CDK)9. Using CDK9 inhibitors and global run-on sequencing (GRO-seq), we have mapped CDK9 inhibitor-sensitive checkpoints genome-wide in hum...
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| Publicado no: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4424039/ https://ncbi.nlm.nih.gov/pubmed/25849141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3000 |
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