PTEN Functions by Recruitment to Cytoplasmic Vesicles

PTEN is proposed to function at the plasma membrane, where receptor tyrosine kinases are activated. However, the majority of PTEN is located throughout the cytoplasm. Here, we show that cytoplasmic PTEN is distributed along microtubules, tethered to vesicles via phosphatidylinositol 3-phosphate (PI(...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Naguib, Adam, Bencze, Gyula, Cho, Hyejin, Zheng, Wu, Tocilj, Ante, Elkayam, Elad, Faehnle, Christopher R., Jaber, Nadia, Pratt, Christopher P., Chen, Muhan, Zong, Wei-Xing, Marks, Michael S., Joshua-Tor, Leemor, Pappin, Darryl J., Trotman, Lloyd C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423730/
https://ncbi.nlm.nih.gov/pubmed/25866245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.03.011
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