PTEN Functions by Recruitment to Cytoplasmic Vesicles

PTEN is proposed to function at the plasma membrane, where receptor tyrosine kinases are activated. However, the majority of PTEN is located throughout the cytoplasm. Here, we show that cytoplasmic PTEN is distributed along microtubules, tethered to vesicles via phosphatidylinositol 3-phosphate (PI(...

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Bibliografiska uppgifter
I publikationen:Mol Cell
Huvudupphovsmän: Naguib, Adam, Bencze, Gyula, Cho, Hyejin, Zheng, Wu, Tocilj, Ante, Elkayam, Elad, Faehnle, Christopher R., Jaber, Nadia, Pratt, Christopher P., Chen, Muhan, Zong, Wei-Xing, Marks, Michael S., Joshua-Tor, Leemor, Pappin, Darryl J., Trotman, Lloyd C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423730/
https://ncbi.nlm.nih.gov/pubmed/25866245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.03.011
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