The BH4 Domain of Anti-apoptotic Bcl-XL, but Not That of the Related Bcl-2, Limits the Voltage-dependent Anion Channel 1 (VDAC1)-mediated Transfer of Pro-apoptotic Ca(2+) Signals to Mitochondria

Excessive Ca(2+) fluxes from the endoplasmic reticulum to the mitochondria result in apoptotic cell death. Bcl-2 and Bcl-XL proteins exert part of their anti-apoptotic function by directly targeting Ca(2+)-transport systems, like the endoplasmic reticulum-localized inositol 1,4,5-trisphosphate recep...

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Publicat a:J Biol Chem
Autors principals: Monaco, Giovanni, Decrock, Elke, Arbel, Nir, van Vliet, Alexander R., La Rovere, Rita M., De Smedt, Humbert, Parys, Jan B., Agostinis, Patrizia, Leybaert, Luc, Shoshan-Barmatz, Varda, Bultynck, Geert
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423701/
https://ncbi.nlm.nih.gov/pubmed/25681439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.622514
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