Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice.

Mice with a homozygous deletion in their Tap-1 gene (-/- mice) express very low levels of cell membrane major histocompatibility complex class I molecules and have < 1% peripheral CD8+ T cells. We show that these -/- mice but not their +/- littermates display strong primary syngeneic anti-H-2Kb a...

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Autors principals: Aldrich, C J, Ljunggren, H G, Van Kaer, L, Ashton-Rickardt, P G, Tonegawa, S, Forman, J
Format: Artigo
Idioma:Inglês
Publicat: 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC44235/
https://ncbi.nlm.nih.gov/pubmed/8022816
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