Mesenchymal stem cells control alloreactive CD8(+)CD28(−) T cells

CD28/B7 co-stimulation blockade with belatacept prevents alloreactivity in kidney transplant patients. However, cells lacking CD28 are not susceptible to belatacept treatment. As CD8(+)CD28(−) T-cells have cytotoxic and pathogenic properties, we investigated whether mesenchymal stem cells (MSC) are...

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Detalhes bibliográficos
Main Authors: Engela, A U, Baan, C C, Litjens, N H R, Franquesa, M, Betjes, M G H, Weimar, W, Hoogduijn, M J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826311/
https://ncbi.nlm.nih.gov/pubmed/24028656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12199
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