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Methylation Abnormalities in Mammary Carcinoma: The Methylation Suicide Hypothesis
Promoter silencing by ectopic de novo methylation of tumor suppressor genes has been proposed as comparable or equivalent to inactivating mutations as a factor in carcinogenesis. However, this hypotheses had not previously been tested by high resolution, high-coverage whole-genome methylation profil...
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| Publicado no: | J Cancer Ther |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4423420/ https://ncbi.nlm.nih.gov/pubmed/25960928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4236/jct.2014.514131 |
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