The NOXA–MCL1–BIM axis defines lifespan on extended mitotic arrest

Cell death on extended mitotic arrest is considered arguably most critical for the efficacy of microtubule-targeting agents (MTAs) in anticancer therapy. While the molecular machinery controlling mitotic arrest on MTA treatment, the spindle assembly checkpoint (SAC), appears well defined, the molecu...

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Udgivet i:Nat Commun
Main Authors: Haschka, Manuel D., Soratroi, Claudia, Kirschnek, Susanne, Häcker, Georg, Hilbe, Richard, Geley, Stephan, Villunger, Andreas, Fava, Luca L.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423218/
https://ncbi.nlm.nih.gov/pubmed/25922916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7891
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