ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction

APOBEC3G (A3G) is an innate antiviral restriction factor that strongly inhibits the replication of human immunodeficiency virus type 1 (HIV-1). An HIV-1 accessory protein, Vif, hijacks the host ubiquitin–proteasome system to execute A3G degradation. Identification of the host pathways that obstruct...

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Publicado no:Nat Commun
Main Authors: Miyakawa, Kei, Matsunaga, Satoko, Kanou, Kazuhiko, Matsuzawa, Atsushi, Morishita, Ryo, Kudoh, Ayumi, Shindo, Keisuke, Yokoyama, Masaru, Sato, Hironori, Kimura, Hirokazu, Tamura, Tomohiko, Yamamoto, Naoki, Ichijo, Hidenori, Takaori-Kondo, Akifumi, Ryo, Akihide
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423214/
https://ncbi.nlm.nih.gov/pubmed/25901786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7945
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