The Folding Unit of Phosphofructokinase-2 as Defined by the Biophysical Properties of a Monomeric Mutant

Escherichia coli phosphofructokinase-2 (Pfk-2) is an obligate homodimer that follows a highly cooperative three-state folding mechanism N(2) ↔ 2I ↔ 2U. The strong coupling between dissociation and unfolding is a consequence of the structural features of its interface: a bimolecular domain formed by...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Ramírez-Sarmiento, César A., Baez, Mauricio, Zamora, Ricardo A., Balasubramaniam, Deepa, Babul, Jorge, Komives, Elizabeth A., Guixé, Victoria
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2015
Assuntos:
Proteins and Nucleic Acids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423062/
https://ncbi.nlm.nih.gov/pubmed/25954892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.04.001
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