Ligand-dependent Enhancer Activation Regulated by Topoisomerase-I Activity

The discovery that enhancers are regulated transcription units, encoding eRNAs, has raised new questions about the mechanisms of their activation. Here, we report an unexpected molecular mechanism that underlies ligand-dependent enhancer activation, based on DNA nicking to relieve torsional stress f...

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Udgivet i:Cell
Main Authors: Puc, Janusz, Kozbial, Piotr, Li, Wenbo, Tan, Yuliang, Liu, Zhijie, Suter, Tom, Ohgi, Kenneth A., Zhang, Jie, Aggarwal, Aneel K., Rosenfeld, Michael G.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422651/
https://ncbi.nlm.nih.gov/pubmed/25619691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.12.023
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