Ligand-dependent Enhancer Activation Regulated by Topoisomerase-I Activity

The discovery that enhancers are regulated transcription units, encoding eRNAs, has raised new questions about the mechanisms of their activation. Here, we report an unexpected molecular mechanism that underlies ligand-dependent enhancer activation, based on DNA nicking to relieve torsional stress f...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Puc, Janusz, Kozbial, Piotr, Li, Wenbo, Tan, Yuliang, Liu, Zhijie, Suter, Tom, Ohgi, Kenneth A., Zhang, Jie, Aggarwal, Aneel K., Rosenfeld, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422651/
https://ncbi.nlm.nih.gov/pubmed/25619691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.12.023
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