Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly

A crucial feature of differentiated cells is the rapid activation of enhancer-driven transcriptional programs in response to signals. The potential contributions of physicochemical properties of enhancer assembly in signaling events remain poorly understood. Here we report that in human breast cance...

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Vydáno v:Nat Struct Mol Biol
Hlavní autoři: Nair, Sreejith J., Yang, Lu, Meluzzi, Dario, Oh, Soohwan, Yang, Feng, Friedman, Meyer J., Wang, Susan, Suter, Tom, Alshareedah, Ibraheem, Gamliel, Amir, Ma, Qi, Zhang, Jie, Hu, Yiren, Tan, Yuliang, Ohgi, Kenneth A., Singh Jayani, Ranveer, Banerjee, Priya R., Aggarwal, Aneel K., Rosenfeld, Michael G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709854/
https://ncbi.nlm.nih.gov/pubmed/30833784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0190-5
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