SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis

Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell–derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization of bone marrow stem cells, limiting their clinical application for metasta...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Dillenburg-Pilla, Patricia, Patel, Vyomesh, Mikelis, Constantinos M., Zárate-Bladés, Carlos Rodrigo, Doçi, Colleen L., Amornphimoltham, Panomwat, Wang, Zhiyong, Martin, Daniel, Leelahavanichkul, Kantima, Dorsam, Robert T., Masedunskas, Andrius, Weigert, Roberto, Molinolo, Alfredo A., Gutkind, J. Silvio
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2015
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422355/
https://ncbi.nlm.nih.gov/pubmed/25466898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-260083
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