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Chk1 activity is required for BAK multimerization in association with PUMA during mitochondrial apoptosis
BACKGROUND: The Bcl-2 protein BAK is a key player in mitochondrial apoptosis and responds to a myriad of different death signals. Activation of BAK is a multistep process that involves a number of conformational changes mediated by BH3-only proteins or p53 which leads to BAK multimerization and pore...
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| Publicado no: | Cell Commun Signal |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4422300/ https://ncbi.nlm.nih.gov/pubmed/25012639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-014-0042-1 |
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