Mutant forms of spectrin alpha-subunits in hereditary elliptocytosis.

Two variant spectrins have been described in hereditary elliptocytosis (HE) and pyropoikilocytosis (HPP). Both are characterized by increased susceptibility of the alpha I (N-terminal) 80-kD domain to mild tryptic digestion, yielding peptides of 46-50 or 65-68 kD (T50a and T68 in our terminology). I...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Marchesi, S L, Letsinger, J T, Speicher, D W, Marchesi, V T, Agre, P, Hyun, B, Gulati, G
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1987
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442218/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3597773/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113047
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