Effects of cytarabine on activation of human T cells – cytarabine has concentration-dependent effects that are modulated both by valproic acid and all-trans retinoic acid

BACKGROUND: Cytarabine is used in the treatment of acute myeloid leukemia (AML). Low-dose cytarabine can be combined with valproic acid and all-trans retinoic acid (ATRA) as AML-stabilizing treatment. We have investigated the possible risk of immunotoxicity by this combination. We examined the effec...

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Bibliographic Details
Published in:BMC Pharmacol Toxicol
Main Authors: Ersvaer, Elisabeth, Brenner, Annette K, Vetås, Kristin, Reikvam, Håkon, Bruserud, Øystein
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422044/
https://ncbi.nlm.nih.gov/pubmed/25934555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-015-0012-2
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