BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells

Osteosarcoma (OS) survival rates have plateaued in part due to a lack of new therapeutic options. Here we demonstrate that bromodomain inhibitors (BETi), JQ1, I-BET151, I-BET762, exert potent anti-tumour activity against primary and established OS cell lines, mediated by inhibition of BRD4. Striking...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Baker, Emma K, Taylor, Scott, Gupte, Ankita, Sharp, Phillip P, Walia, Mannu, Walsh, Nicole C, Zannettino, Andrew CW, Chalk, Alistair M, Burns, Christopher J, Walkley, Carl R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4421868/
https://ncbi.nlm.nih.gov/pubmed/25944566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10120
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