Effects of Atrazine on Estrogen Receptor α– and G Protein–Coupled Receptor 30–Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts

Background: The pesticide atrazine does not bind to or activate the classical estrogen receptor (ER), but it up-regulates the aromatase activity in estrogen-sensitive tumor cells. The G protein estrogen receptor (GPR30/GPER) has been reported to be involved in certain biological responses to endogen...

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Veröffentlicht in:Environ Health Perspect
Hauptverfasser: Albanito, Lidia, Lappano, Rosamaria, Madeo, Antonio, Chimento, Adele, Prossnitz, Eric R., Cappello, Anna Rita, Dolce, Vincenza, Abonante, Sergio, Pezzi, Vincenzo, Maggiolini, Marcello
Format: Artigo
Sprache:Inglês
Veröffentlicht: NLM-Export 2015
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4421771/
https://ncbi.nlm.nih.gov/pubmed/25616260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1408586
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