G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L

Autophagy is an important intracellular catabolic mechanism involved in the removal of misfolded proteins. Atg14L, the mammalian ortholog of Atg14 in yeast and a critical regulator of autophagy, mediates the production PtdIns3P to initiate the formation of autophagosomes. However, it is not clear ho...

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Udgivet i:eLife
Main Authors: Zhang, Tao, Dong, Kangyun, Liang, Wei, Xu, Daichao, Xia, Hongguang, Geng, Jiefei, Najafov, Ayaz, Liu, Min, Li, Yanxia, Han, Xiaoran, Xiao, Juan, Jin, Zhenzhen, Peng, Ting, Gao, Yang, Cai, Yu, Qi, Chunting, Zhang, Qing, Sun, Anyang, Lipinski, Marta, Zhu, Hong, Xiong, Yue, Pandolfi, Pier Paolo, Li, He, Yu, Qiang, Yuan, Junying
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2015
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4421748/
https://ncbi.nlm.nih.gov/pubmed/25821988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06734
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