SNP Discovery in Pooled Samples With Mismatch Repair Detection

A targeted discovery effort is required to identify low frequency single nucleotide polymorphisms (SNPs) in human coding and regulatory regions. We here describe combining mismatch repair detection (MRD) with dideoxy terminator sequencing to detect SNPs in pooled DNA samples. MRD enriches for varian...

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Autori principali: Fakhrai-Rad, Hossein, Zheng, Jianbiao, Willis, Thomas D., Wong, Kee, Suyenaga, Kent, Moorhead, Martin, Eberle, Jim, Thorstenson, Yvonne R., Jones, Ted, Davis, Ronald W., Namsaraev, Eugeni, Faham, Malek
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2004
Soggetti:
Methods
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC442157/
https://ncbi.nlm.nih.gov/pubmed/15231755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.2373904
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