Gene Expression From the Aneuploid Chromosome in a Trisomy Mouse Model of Down Syndrome

Trisomy 21 is the prototype of human aneuploidies. Since its discovery in 1959, the hypothesis has been that overexpression of the ∼230 human chromosome 21 (Hsa21) genes result in the complex phenotype. However, the level of overexpression of Hsa21 genes in trisomic individuals is presently unknown....

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Pubblicato in:	Genome Res
Autori principali:	Lyle, Robert, Gehrig, Corinne, Neergaard-Henrichsen, Charlotte, Deutsch, Samuel, Antonarakis, Stylianos E.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 2004
Soggetti:	Letters
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442141/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15231743/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gr.2090904
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