Transcript Level Alterations Reflect Gene Dosage Effects Across Multiple Tissues in a Mouse Model of Down Syndrome

Human trisomy 21, which results in Down syndrome (DS), is one of the most complicated congenital genetic anomalies compatible with life, yet little is known about the molecular basis of DS. It is generally accepted that chromosome 21 (Chr21) transcripts are overexpressed by about 50% in cells with a...

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Detalhes bibliográficos
Main Authors: Kahlem, Pascal, Sultan, Marc, Herwig, Ralf, Steinfath, Matthias, Balzereit, Daniela, Eppens, Barbara, Saran, Nidhi G., Pletcher, Mathew T., South, Sarah T., Stetten, Gail, Lehrach, Hans, Reeves, Roger H., Yaspo, Marie-Laure
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Letters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC442140/
https://ncbi.nlm.nih.gov/pubmed/15231742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.1951304
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