Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding

Highly polymorphic major histocompatibility complex (MHC) molecules are at the heart of adaptive immune responses, playing crucial roles in many kinds of disease and in vaccination. We report that breadth of peptide presentation and level of cell surface expression of class I molecules are inversely...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Chappell, Paul E, Meziane, El Kahina, Harrison, Michael, Magiera, Łukasz, Hermann, Clemens, Mears, Laura, Wrobel, Antoni G, Durant, Charlotte, Nielsen, Lise Lotte, Buus, Søren, Ternette, Nicola, Mwangi, William, Butter, Colin, Nair, Venugopal, Ahyee, Trudy, Duggleby, Richard, Madrigal, Alejandro, Roversi, Pietro, Lea, Susan M, Kaufman, Jim
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2015
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420994/
https://ncbi.nlm.nih.gov/pubmed/25860507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05345
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