The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice

Splicing factors (SFs) coordinate nuclear intron/exon splicing of RNA. Splicing factor disturbances can cause cell death. RNA binding motif 5 (RBM5) and 10 (RBM10) promote apoptosis in cancer cells by activating detrimental alternative splicing of key death/survival genes. The role(s) of RBM5/10 in...

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Publicado en:J Cereb Blood Flow Metab
Autores principales: Jackson, Travis C, Du, Lina, Janesko-Feldman, Keri, Vagni, Vincent A, Dezfulian, Cameron, Poloyac, Samuel M, Jackson, Edwin K, Clark, Robert SB, Kochanek, Patrick M
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420885/
https://ncbi.nlm.nih.gov/pubmed/25586139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.242
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