Glibenclamide Produces Region-Dependent Effects on Cerebral Edema in a Combined Injury Model of Traumatic Brain Injury and Hemorrhagic Shock in Mice

Cerebral edema is critical to morbidity/mortality in traumatic brain injury (TBI) and is worsened by hypotension. Glibenclamide may reduce cerebral edema by inhibiting sulfonylurea receptor-1 (Sur1); its effect on diffuse cerebral edema exacerbated by hypotension/resuscitation is unknown. We aimed t...

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Detalhes bibliográficos
Publicado no:J Neurotrauma
Main Authors: Jha, Ruchira M., Molyneaux, Bradley J., Jackson, Travis C., Wallisch, Jessica S., Park, Seo-Young, Poloyac, Samuel, Vagni, Vincent A., Janesko-Feldman, Keri L., Hoshitsuki, Keito, Minnigh, M. Beth, Kochanek, Patrick M.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2018
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6098411/
https://ncbi.nlm.nih.gov/pubmed/29648981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2016.4696
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