Single-Molecule Imaging of PSD-95 mRNA Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome

Fragile X syndrome (FXS) is caused by the loss of the fragile X mental retardation protein (FMRP), an RNA binding protein that regulates translation of numerous target mRNAs, some of which are dendritically localized. Our previous biochemical studies using synaptoneurosomes demonstrate a role for FM...

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Vydáno v:J Neurosci
Hlavní autoři: Ifrim, Marius F., Williams, Kathryn R., Bassell, Gary J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2015
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420780/
https://ncbi.nlm.nih.gov/pubmed/25948262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2802-14.2015
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