A structure-function study of PACAP using conformationally-restricted analogs: identification of PAC1 receptor-selective PACAP agonists

Pituitary adenylate-cyclase-activating polypeptide (PACAP) has widespread physiological/pathophysiological actions and there is increased interest for its use therapeutically, especially in the CNS (neuroprotection). Unfortunately, no selective PACAP-analogs exist for PACAP-preferring PAC1-receptors...

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Detalhes bibliográficos
Publicado no:Peptides
Main Authors: Ramos-Álvarez, Irene, Mantey, Samuel A., Nakamura, Taichi, Nuche-Berenguer, Bernardo, Moreno, Paola, Moody, Terry W., Maderdrut, Jerome L., Coy, David H., Jensen, Robert T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420714/
https://ncbi.nlm.nih.gov/pubmed/25698233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2015.01.009
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