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Pharmacological inhibition of ALDH1A in mice decreases all-trans retinoic acid concentrations in a tissue specific manner

all-trans retinoic acid (atRA), the active metabolite of vitamin A, is an essential signaling molecule. Specifically the concentrations of atRA are spatiotemporally controlled in target tissues such as the liver and the testes. While the enzymes of the aldehyde dehydrogenase 1A family (ALDH1A) are b...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochem Pharmacol
Prif Awduron: Arnold, Samuel L. M., Kent, Travis, Hogarth, Cathryn A., Griswold, Michael D., Amory, John K., Isoherranen, Nina
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420653/
https://ncbi.nlm.nih.gov/pubmed/25764981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.03.001
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