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Does deamidation cause protein unfolding? A top-down tandem mass spectrometry study

Deamidation is a nonenzymatic post-translational modification of asparagine to aspartic acid or glutamine to glutamic acid, converting an uncharged amino acid to a negatively charged residue. It is plausible that deamidation of asparagine and glutamine residues would result in disruption of a protei...

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Foilsithe in:Protein Sci
Main Authors: Soulby, Andrew J, Heal, Jack W, Barrow, Mark P, Roemer, Rudolf A, O'Connor, Peter B
Formáid: Artigo
Teanga:Inglês
Foilsithe: BlackWell Publishing Ltd 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420533/
https://ncbi.nlm.nih.gov/pubmed/25653127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2659
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