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Hydrogen exchange of disordered proteins in Escherichia coli

A truly disordered protein lacks a stable fold and its backbone amide protons exchange with solvent at rates predicted from studies of unstructured peptides. We have measured the exchange rates of two model disordered proteins, FlgM and α-synuclein, in buffer and in Escherichia coli using the NMR ex...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Smith, Austin E, Zhou, Larry Z, Pielak, Gary J
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420520/
https://ncbi.nlm.nih.gov/pubmed/25611326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2643
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