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Codelivery of antigen and an immune cell adhesion inhibitor is necessary for efficacy of soluble antigen arrays in experimental autoimmune encephalomyelitis

Autoimmune diseases such as multiple sclerosis (MS) are typified by the misrecognition of self-antigen and the clonal expansion of autoreactive T cells. Antigen-specific immunotherapies (antigen-SITs) have long been explored as a means to desensitize patients to offending self-antigen(s) with the po...

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Publicado en:Mol Ther Methods Clin Dev
Main Authors: Sestak, Joshua O, Sullivan, Bradley P, Thati, Sharadvi, Northrup, Laura, Hartwell, Brittany, Antunez, Lorena, Forrest, M Laird, Vines, Charlotte M, Siahaan, Teruna J, Berkland, Cory
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420258/
https://ncbi.nlm.nih.gov/pubmed/26015953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2014.8
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