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Molecular Evolution of the CYP2D Subfamily in Primates: Purifying Selection on Substrate Recognition Sites without the Frequent or Long-Tract Gene Conversion

The human cytochrome P450 (CYP) 2D6 gene is a member of the CYP2D gene subfamily, along with the CYP2D7P and CYP2D8P pseudogenes. Although the CYP2D6 enzyme has been studied extensively because of its clinical importance, the evolution of the CYP2D subfamily has not yet been fully understood. Theref...

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Detalhes bibliográficos
Publicado no:Genome Biol Evol
Main Authors: Yasukochi, Yoshiki, Satta, Yoko
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4419802/
https://ncbi.nlm.nih.gov/pubmed/25808902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evv056
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