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Strong foreign promoters contribute to innate inflammatory responses induced by adenovirus transducing vectors

E1-deleted adenovirus (FG Ad) transducing vectors are limited for use in vivo by their induction of strong innate and adaptive inflammatory responses. We have examined the contribution of the transgene cassette, particularly the foreign promoter driving transgene expression, in the induction of inna...

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Bibliographic Details
Published in:Virology
Main Authors: Schaack, Jerome, Bennett, Michael L., Shapiro, Gary S., DeGregori, James, McManaman, James L., Moorhead, John W.
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4419336/
https://ncbi.nlm.nih.gov/pubmed/21255815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.12.054
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