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Strong foreign promoters contribute to innate inflammatory responses induced by adenovirus transducing vectors

E1-deleted adenovirus (FG Ad) transducing vectors are limited for use in vivo by their induction of strong innate and adaptive inflammatory responses. We have examined the contribution of the transgene cassette, particularly the foreign promoter driving transgene expression, in the induction of inna...

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Bibliografski detalji
Izdano u:Virology
Glavni autori: Schaack, Jerome, Bennett, Michael L., Shapiro, Gary S., DeGregori, James, McManaman, James L., Moorhead, John W.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4419336/
https://ncbi.nlm.nih.gov/pubmed/21255815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.12.054
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