The effect of food on the pharmacokinetics of oral ibrutinib in healthy participants and patients with chronic lymphocytic leukemia

PURPOSE: To assess ibrutinib pharmacokinetics under fasted and fed conditions, impact of food-intake timing, and the safety and tolerability. METHODS: Three studies were analyzed. Study 1 was a randomized, open-label, single-dose, four-way crossover study in 44 healthy participants. Study 2 was a ra...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: de Jong, Jan, Sukbuntherng, Juthamas, Skee, Donna, Murphy, Joe, O’Brien, Susan, Byrd, John C., James, Danelle, Hellemans, Peter, Loury, David J., Jiao, Juhui, Chauhan, Vijay, Mannaert, Erik
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4419161/
https://ncbi.nlm.nih.gov/pubmed/25724156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2708-9
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