Blocking anaplerotic entry of glutamine to TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs

Cancer cells undergo a metabolic transformation that allows for increased anabolic demands wherein glycolytic and TCA cycle intermediates are shunted away for the synthesis of biological molecules required for cell growth and division. One of the key shunts is the exit of citrate from the mitochondr...

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Vydáno v:Oncogene
Hlavní autoři: Saqcena, Mahesh, Mukhopadhyay, Suman, Hosny, Carol, Alhamed, Arwa, Chatterjee, Amrita, Foster, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418945/
https://ncbi.nlm.nih.gov/pubmed/25023699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.207
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