Cardiolipin-deficient cells depend on anaplerotic pathways to ameliorate defective TCA cycle function

Previous studies have shown that the cardiolipin (CL)-deficient yeast mutant, crd1Δ, has decreased levels of acetyl-CoA and decreased activities of the TCA cycle enzymes aconitase and succinate dehydrogenase. These biochemical phenotypes are expected to lead to defective TCA cycle function. In this...

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Publicat a:Biochim Biophys Acta Mol Cell Biol Lipids
Autors principals: Raja, Vaishnavi, Salsaa, Michael, Joshi, Amit S., Li, Yiran, van Roermund, Carlo W T, Saadat, Nadia, Lazcano, Pablo, Schmidtke, Michael, Hüttemann, Maik, Gupta, Smiti V., Wanders, Ronald J.A., Greenberg, Miriam L.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639082/
https://ncbi.nlm.nih.gov/pubmed/30731133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2019.02.001
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