Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury

Although inhibition of cyclic nucleotide phosphodiesterase type 3 (PDE3) has been reported to protect rodent heart against ischemia/reperfusion (I/R) injury, neither the specific PDE3 isoform involved nor the underlying mechanisms have been identified. Targeted disruption of PDE3 subfamily B (PDE3B)...

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Chung, Youn Wook, Lagranha, Claudia, Chen, Yong, Sun, Junhui, Tong, Guang, Hockman, Steven C., Ahmad, Faiyaz, Esfahani, Shervin G., Bae, Dahae H., Polidovitch, Nazari, Wu, Jian, Rhee, Dong Keun, Lee, Beom Seob, Gucek, Marjan, Daniels, Mathew P., Brantner, Christine A., Backx, Peter H., Murphy, Elizabeth, Manganiello, Vincent C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2015
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PNAS Plus
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418886/
https://ncbi.nlm.nih.gov/pubmed/25877153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416230112
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