Induced transcription and stability of CELF2 mRNA drives widespread alternative splicing during T-cell signaling

Studies in several cell types have highlighted dramatic and diverse changes in mRNA processing that occur upon cellular stimulation. However, the mechanisms and pathways that lead to regulated changes in mRNA processing remain poorly understood. Here we demonstrate that expression of the splicing fa...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mallory, Michael J., Allon, Samuel J., Qiu, Jinsong, Gazzara, Matthew R., Tapescu, Iulia, Martinez, Nicole M., Fu, Xiang-Dong, Lynch, Kristen W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418860/
https://ncbi.nlm.nih.gov/pubmed/25870297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423695112
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