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Signal- and Development-Dependent Alternative Splicing of LEF1 in T Cells Is Controlled by CELF2

The HMG-box transcription factor LEF1 controls many developmentally regulated genes, including genes that activate expression of the T-cell antigen receptor alpha chain (TCR-alpha) in developing thymocytes. At least two distinct isoforms of LEF1 are expressed, resulting from variable inclusion of LE...

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Autors principals: Mallory, Michael J., Jackson, Jason, Weber, Brittany, Chi, Anthony, Heyd, Florian, Lynch, Kristen W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133246/
https://ncbi.nlm.nih.gov/pubmed/21444716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05170-11
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