Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles

Meiosis in mammalian oocytes is paused until luteinizing hormone (LH) activates receptors in the mural granulosa cells of the ovarian follicle. Prior work has established the central role of cyclic GMP (cGMP) from the granulosa cells in maintaining meiotic arrest, but it is not clear how binding of...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Shuhaibar, Leia C., Egbert, Jeremy R., Norris, Rachael P., Lampe, Paul D., Nikolaev, Viacheslav O., Thunemann, Martin, Wen, Lai, Feil, Robert, Jaffe, Laurinda A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418852/
https://ncbi.nlm.nih.gov/pubmed/25775542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423598112
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