A Synthetic Lethal Screen Identifies a Role for Lin-44/Wnt in C. elegans Embryogenesis

BACKGROUND: The C. elegans proteins PTP-3/LAR-RPTP and SDN-1/Syndecan are conserved cell adhesion molecules. Loss-of-function (LOF) mutations in either ptp-3 or sdn-1 result in low penetrance embryonic developmental defects. Work from other systems has shown that syndecans can function as ligands fo...

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Udgivet i:PLoS One
Main Authors: Hartin, Samantha N., Hudson, Martin L., Yingling, Curtis, Ackley, Brian D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418752/
https://ncbi.nlm.nih.gov/pubmed/25938228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121397
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