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Tunable Loading of Oligonucleotides with Secondary Structure on Gold Nanoparticles through a pH-Driven Method

This paper describes how pH can be used to control covalent attachment of oligonucleotides with secondary structure on gold nanoparticles (AuNPs). The highest loading of thiolated nucleic acids occurred at low pH (pH = 1.7) due to reduced repulsion between the negatively charged oligonucleotides and...

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Detalhes bibliográficos
Publicado no:Bioconjug Chem
Main Authors: Dam, Duncan Hieu M., Lee, Hyojin, Lee, Raymond C., Kim, Ki Hun, Kelleher, Neil L., Odom, Teri W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418649/
https://ncbi.nlm.nih.gov/pubmed/25564799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc500562s
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