Grafting Aptamers onto Gold Nanostars Increases in Vitro Efficacy in a Wide Range of Cancer Cell Types

[Image: see text] We report the design of a nanoconstruct that can function as a cell-type independent agent by targeting the ubiquitous protein nucleolin. Gold nanostars (AuNS) loaded with high densities of nucleolin-specific DNA aptamer AS1411 (Apt-AuNS) produced anticancer effects in a panel of 1...

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Bibliographic Details
Main Authors: Dam, Duncan Hieu M., Culver, Kayla S. B., Odom, Teri W.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974612/
https://ncbi.nlm.nih.gov/pubmed/24422969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp4005657
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