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Molecular Details of α-Synuclein Membrane Association Revealed by Neutrons and Photons

α-Synuclein (α-syn) is an abundant neuronal protein associated with Parkinson’s disease that is disordered in solution, but exists in equilibrium between a bent- and an elongated-helix on negatively charged membranes. Here, neutron reflectometry (NR) and fluorescence spectroscopy were employed to un...

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Veröffentlicht in:J Phys Chem B
Hauptverfasser: Jiang, Zhiping, Hess, Sara K., Heinrich, Frank, Lee, Jennifer C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418488/
https://ncbi.nlm.nih.gov/pubmed/25790164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp512499r
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