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Tandutinib inhibits the Akt/mTOR signaling pathway to inhibit colon cancer growth
The c-Kit receptor can activate distinct signaling pathways including phosphatidylinositol-3-kinase (PI3K)/Akt and mammalian target of rapamycin (mTOR). Aberrant c-Kit activation protects cells from apoptosis and enhances invasion of colon carcinoma cells. Tandutinib is a novel quinazoline-based inh...
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| Publicado no: | Mol Cancer Ther |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4418457/ https://ncbi.nlm.nih.gov/pubmed/23427297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0907 |
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