Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras

Several genetically engineered mouse (GEM) models of colorectal cancer have been developed and are a mainstay in our efforts to identify means of preventing and treating this disease. Many of these models involve a germline disruption of the adenomatous polyposis coli (Apc) tumor suppressor gene and...

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Udgivet i:Cancer Lett
Main Authors: Byun, Alexander, Hung, Kenneth E., Fleet, James C., Bronson, Roderick T., Mason, Joel B., Garcia, Paloma E., Crott, Jimmy W.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418438/
https://ncbi.nlm.nih.gov/pubmed/24632531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2014.03.004
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