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Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras
Several genetically engineered mouse (GEM) models of colorectal cancer have been developed and are a mainstay in our efforts to identify means of preventing and treating this disease. Many of these models involve a germline disruption of the adenomatous polyposis coli (Apc) tumor suppressor gene and...
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| Publicado no: | Cancer Lett |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4418438/ https://ncbi.nlm.nih.gov/pubmed/24632531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2014.03.004 |
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