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The synaptotagmin 1 linker may function as an electrostatic zipper that opens for docking but closes for fusion pore opening
Syt1 (synaptotagmin 1), a major Ca(2+) sensor for fast neurotransmitter release, contains tandem Ca(2+)-binding C2 domains (C2AB), a single transmembrane α-helix and a highly charged 60-residue-long linker in between. Using single-vesicle-docking and content-mixing assays we found that the linker re...
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| Publicado en: | Biochem J |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4418238/ https://ncbi.nlm.nih.gov/pubmed/24001110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20130949 |
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