Identification of recurrent SMO and BRAF mutations in ameloblastomas

Here we report the discovery of oncogenic mutations in the Hedgehog and mitogen-activated protein kinase (MAPK) pathways in over 80% of ameloblastomas, locally destructive odontogenic tumors of the jaw, by genomic analysis of archival material. Mutations in SMO (encoding Smoothened, SMO) are common...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Sweeney, Robert T, McClary, Andrew C, Myers, Benjamin R, Biscocho, Jewison, Neahring, Lila, Kwei, Kevin A, Qu, Kunbin, Gong, Xue, Ng, Tony, Jones, Carol D, Varma, Sushama, Odegaard, Justin I, Sugiyama, Toshihiro, Koyota, Souichi, Rubin, Brian P, Troxell, Megan L, Pelham, Robert J, Zehnder, James L, Beachy, Philip A, Pollack, Jonathan R, West, Robert B
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418232/
https://ncbi.nlm.nih.gov/pubmed/24859340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2986
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