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Endosomal generation of cAMP in GPCR signaling

It has been widely assumed that the production of the ubiquitous second messenger cyclic AMP, which is mediated by cell surface G protein–coupled receptors (GPCRs), and its termination take place exclusively at the plasma membrane. Recent studies reveal that diverse GPCRs do not always follow this c...

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Bibliografiske detaljer
Udgivet i:Nat Chem Biol
Main Authors: Vilardaga, Jean-Pierre, Jean-Alphonse, Frederic G., Gardella, Thomas J.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417940/
https://ncbi.nlm.nih.gov/pubmed/25271346
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